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1p0z

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[[Image:1p0z.gif|left|200px]]
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{{STRUCTURE_1p0z| PDB=1p0z | SCENE= }}
{{STRUCTURE_1p0z| PDB=1p0z | SCENE= }}
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'''Sensor Kinase CitA binding domain'''
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===Sensor Kinase CitA binding domain===
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==Overview==
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The integral membrane sensor kinase CitA of Klebsiella pneumoniae is part of a two-component signal transduction system that regulates the transport and metabolism of citrate in response to its environmental concentration. Two-component systems are widely used by bacteria for such adaptive processes, but the stereochemistry of periplasmic ligand binding and the mechanism of signal transduction across the membrane remain poorly understood. The crystal structure of the CitAP periplasmic sensor domain in complex with citrate reveals a PAS fold, a versatile ligand-binding structural motif that has not previously been observed outside the cytoplasm or implicated in the transduction of conformational signals across the membrane. Citrate is bound in a pocket that is shared among many PAS domains but that shows structural variation according to the nature of the bound ligand. In CitAP, some of the citrate contact residues are located in the final strand of the central beta-sheet, which is connected to the C-terminal transmembrane helix. These secondary structure elements thus provide a potential conformational link between the periplasmic ligand binding site and the cytoplasmic signaling domains of the receptor.
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(as it appears on PubMed at http://www.pubmed.gov), where 12867417 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12867417}}
==About this Structure==
==About this Structure==
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[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:10:17 2008''

Revision as of 14:10, 28 July 2008

Image:1p0z.png

Template:STRUCTURE 1p0z

Sensor Kinase CitA binding domain

Template:ABSTRACT PUBMED 12867417

About this Structure

1P0Z is a Single protein structure of sequence from Klebsiella pneumoniae. Full crystallographic information is available from OCA.

Reference

The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain., Reinelt S, Hofmann E, Gerharz T, Bott M, Madden DR, J Biol Chem. 2003 Oct 3;278(40):39189-96. Epub 2003 Jul 16. PMID:12867417

Page seeded by OCA on Mon Jul 28 17:10:17 2008

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