1p16

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[[Image:1p16.gif|left|200px]]
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{{Seed}}
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[[Image:1p16.png|left|200px]]
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{{STRUCTURE_1p16| PDB=1p16 | SCENE= }}
{{STRUCTURE_1p16| PDB=1p16 | SCENE= }}
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'''Structure of an mRNA capping enzyme bound to the phosphorylated carboxyl-terminal domain of RNA polymerase II'''
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===Structure of an mRNA capping enzyme bound to the phosphorylated carboxyl-terminal domain of RNA polymerase II===
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==Overview==
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The 2.7 A structure of Candida albicans RNA guanylyltransferase Cgt1 cocrystallized with a carboxy-terminal domain (CTD) peptide composed of four Ser5-PO4 YSPTSPS heptad repeats illuminates distinct CTD-docking sites localized to the Cgt1 N-terminal nucleotidyl transferase domain. Tyr1, Pro3, Pro6, and Ser5-PO4 side chains from each of two YSPTSPS repeats contribute to the interface. Comparison to the Pin1-CTD structure shows that the CTD can assume markedly different conformations that are templated by particular binding partners. Structural plasticity combined with remodeling of CTD primary structure by kinases and phosphatases provides a versatile mechanism by which the CTD can recruit structurally dissimilar proteins during transcription. A binding site for the RNA triphosphatase component of the capping apparatus was also uncovered within the Cgt1 OB domain.
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The line below this paragraph, {{ABSTRACT_PUBMED_12820968}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12820968 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12820968}}
==About this Structure==
==About this Structure==
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[[Category: Rna polymerase ii]]
[[Category: Rna polymerase ii]]
[[Category: Transcription]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:33:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:52:18 2008''

Revision as of 15:52, 27 July 2008

Image:1p16.png

Template:STRUCTURE 1p16

Structure of an mRNA capping enzyme bound to the phosphorylated carboxyl-terminal domain of RNA polymerase II

Template:ABSTRACT PUBMED 12820968

About this Structure

1P16 is a Single protein structure of sequence from Candida albicans. Full crystallographic information is available from OCA.

Reference

Structure of an mRNA capping enzyme bound to the phosphorylated carboxy-terminal domain of RNA polymerase II., Fabrega C, Shen V, Shuman S, Lima CD, Mol Cell. 2003 Jun;11(6):1549-61. PMID:12820968

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