1p2v

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[[Image:1p2v.jpg|left|200px]]
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{{Seed}}
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[[Image:1p2v.png|left|200px]]
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{{STRUCTURE_1p2v| PDB=1p2v | SCENE= }}
{{STRUCTURE_1p2v| PDB=1p2v | SCENE= }}
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'''H-RAS 166 in 60 % 1,6 hexanediol'''
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===H-RAS 166 in 60 % 1,6 hexanediol===
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==Overview==
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Room temperature crystal structures of crosslinked H-Ras bound to GMPPNP were solved in 50% 2,2,2-trifluoroethanol, 60% 1,6-hexanediol, and 50% isopropanol. The disordered switch II region of Ras is ordered in the presence of 2,2,2-trifluoroethanol or 1,6-hexanediol. The overall backbone conformation of switch II in these organic solvents is the same as in the Ras-GMPPNP complexes with RalGDS, PI(3) kinase, and RasGAP, indicating a biologically relevant form. Key polar interactions that stabilize the ordered switch are enhanced in the presence of hydrophobic cosolvents. These results suggest that hydrophobic solvents can be used in general to order short biologically relevant segments of disordered regions in protein crystals by favoring H-bonding interactions between atoms that are highly solvated and mobile in aqueous solution.
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(as it appears on PubMed at http://www.pubmed.gov), where 12842038 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12842038}}
==About this Structure==
==About this Structure==
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[[Category: Molecular switch protein]]
[[Category: Molecular switch protein]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:36:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:32:54 2008''

Revision as of 03:33, 28 July 2008

Image:1p2v.png

Template:STRUCTURE 1p2v

H-RAS 166 in 60 % 1,6 hexanediol

Template:ABSTRACT PUBMED 12842038

About this Structure

1P2V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Organic solvents order the dynamic switch II in Ras crystals., Buhrman G, de Serrano V, Mattos C, Structure. 2003 Jul;11(7):747-51. PMID:12842038

Page seeded by OCA on Mon Jul 28 06:32:54 2008

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