This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1qnd
From Proteopedia
(New page: 200px<br /> <applet load="1qnd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qnd" /> '''STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURE...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1qnd.gif|left|200px]]<br /> | + | [[Image:1qnd.gif|left|200px]]<br /><applet load="1qnd" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1qnd" size=" | + | |
caption="1qnd" /> | caption="1qnd" /> | ||
'''STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES'''<br /> | '''STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1QND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1QND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QND OCA]. |
==Reference== | ==Reference== | ||
| Line 27: | Line 26: | ||
[[Category: sterol carrier protein 2]] | [[Category: sterol carrier protein 2]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:45:21 2008'' |
Revision as of 14:45, 15 February 2008
|
STEROL CARRIER PROTEIN-2, NMR, 20 STRUCTURES
Overview
The determination of the NMR structure of the sterol carrier protein-2, (SCP2), analysis of backbone (15)N spin relaxation parameters and NMR, studies of nitroxide spin-labeled substrate binding are presented as a new, basis for investigations of the mode of action of SCP2. The SCP2 fold is, formed by a five-stranded beta-sheet and four alpha-helices. Fatty acid, binding to a hydrophobic surface area formed by amino acid residues of the, first and third helices, and the beta-sheet, which are all located in the, polypeptide segment 8-102, was identified with the use of the spin-labeled, substrate 16-doxylstearic acid. In the free protein, the lipid-binding, site is covered by the C-terminal segment 105-123, suggesting that this, polypeptide segment, which carries the peroxisomal targeting signal, (PTS1), might be involved in the regulation of ligand binding.
About this Structure
1QND is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
NMR structure of the sterol carrier protein-2: implications for the biological role., Garcia FL, Szyperski T, Dyer JH, Choinowski T, Seedorf U, Hauser H, Wuthrich K, J Mol Biol. 2000 Jan 21;295(3):595-603. PMID:10623549
Page seeded by OCA on Fri Feb 15 16:45:21 2008
