1p4l

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[[Image:1p4l.gif|left|200px]]
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{{Seed}}
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[[Image:1p4l.png|left|200px]]
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{{STRUCTURE_1p4l| PDB=1p4l | SCENE= }}
{{STRUCTURE_1p4l| PDB=1p4l | SCENE= }}
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'''Crystal structure of NK receptor Ly49C mutant with its MHC class I ligand H-2Kb'''
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===Crystal structure of NK receptor Ly49C mutant with its MHC class I ligand H-2Kb===
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==Overview==
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The Ly49 family of natural killer (NK) receptors regulates NK cell function by sensing major histocompatibility complex (MHC) class I. Ly49 receptors show complex patterns of MHC class I cross-reactivity and, in certain cases, peptide selectivity. To investigate whether specificity differences result from topological differences in MHC class I engagement, we determined the structure of the peptide-selective receptor Ly49C in complex with H-2K(b). The Ly49C homodimer binds two MHC class I molecules in symmetrical way, a mode distinct from that of Ly49A, which binds MHC class I asymmetrically. Ly49C does not directly contact the MHC-bound peptide. In addition, MHC crosslinking by Ly49C was demonstrated in solution. We propose a dynamic model for Ly49-MHC class I interactions involving conformational changes in the receptor, whereby variations in Ly49 dimerization mediate different MHC-binding modes.
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The line below this paragraph, {{ABSTRACT_PUBMED_14595439}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14595439 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14595439}}
==About this Structure==
==About this Structure==
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[[Category: Mhc class i]]
[[Category: Mhc class i]]
[[Category: Natural killer receptor]]
[[Category: Natural killer receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:40:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:26:53 2008''

Revision as of 01:26, 29 July 2008

Image:1p4l.png

Template:STRUCTURE 1p4l

Crystal structure of NK receptor Ly49C mutant with its MHC class I ligand H-2Kb

Template:ABSTRACT PUBMED 14595439

About this Structure

1P4L is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b)., Dam J, Guan R, Natarajan K, Dimasi N, Chlewicki LK, Kranz DM, Schuck P, Margulies DH, Mariuzza RA, Nat Immunol. 2003 Dec;4(12):1213-22. Epub 2003 Nov 2. PMID:14595439

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