1p5u

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[[Image:1p5u.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1p5u| PDB=1p5u | SCENE= }}
{{STRUCTURE_1p5u| PDB=1p5u | SCENE= }}
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'''X-ray structure of the ternary Caf1M:Caf1:Caf1 chaperone:subunit:subunit complex'''
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===X-ray structure of the ternary Caf1M:Caf1:Caf1 chaperone:subunit:subunit complex===
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==Overview==
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Most gram-negative pathogens express fibrous adhesive virulence organelles that mediate targeting to the sites of infection. The F1 capsular antigen from the plague pathogen Yersinia pestis consists of linear fibers of a single subunit (Caf1) and serves as a prototype for nonpilus organelles assembled via the chaperone/usher pathway. Genetic data together with high-resolution X-ray structures corresponding to snapshots of the assembly process reveal the structural basis of fiber formation. Comparison of chaperone bound Caf1 subunit with the subunit in the fiber reveals a novel type of conformational change involving the entire hydrophobic core of the protein. The observed conformational change suggests that the chaperone traps a high-energy folding intermediate of Caf1. A model is proposed in which release of the subunit allows folding to be completed, driving fiber formation.
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(as it appears on PubMed at http://www.pubmed.gov), where 12787500 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12787500}}
==About this Structure==
==About this Structure==
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[[Category: Donor strand exchange]]
[[Category: Donor strand exchange]]
[[Category: Protein fiber]]
[[Category: Protein fiber]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:43:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:03:45 2008''

Revision as of 12:03, 27 July 2008

Image:1p5u.png

Template:STRUCTURE 1p5u

X-ray structure of the ternary Caf1M:Caf1:Caf1 chaperone:subunit:subunit complex

Template:ABSTRACT PUBMED 12787500

About this Structure

1P5U is a Protein complex structure of sequences from Yersinia pestis. Full crystallographic information is available from OCA.

Reference

Structure and biogenesis of the capsular F1 antigen from Yersinia pestis: preserved folding energy drives fiber formation., Zavialov AV, Berglund J, Pudney AF, Fooks LJ, Ibrahim TM, MacIntyre S, Knight SD, Cell. 2003 May 30;113(5):587-96. PMID:12787500

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