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1p7h

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[[Image:1p7h.gif|left|200px]]
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{{STRUCTURE_1p7h| PDB=1p7h | SCENE= }}
{{STRUCTURE_1p7h| PDB=1p7h | SCENE= }}
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'''Structure of NFAT1 bound as a dimer to the HIV-1 LTR kB element'''
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===Structure of NFAT1 bound as a dimer to the HIV-1 LTR kB element===
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==Overview==
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DNA binding by NFAT1 as a dimer has been implicated in the activation of host and viral genes. Here we report a crystal structure of NFAT1 bound cooperatively as a dimer to the highly conserved kappa B site from the human immunodeficiency virus 1 (HIV-1) long terminal repeat (LTR). This structure reveals a new mode of dimerization and protein-DNA recognition by the Rel homology region (RHR) of NFAT1. The two NFAT1 monomers form a complete circle around the kappa B DNA through protein-protein interactions mediated by both their N- and C-terminal subdomains. The major dimer interface, formed by the C-terminal domain, is asymmetric and substantially different from the symmetric dimer interface seen in other Rel family proteins. Comparison to other NFAT structures, including NFAT5 and the NFAT1-Fos-Jun-ARRE2 complex, reveals that NFAT1 adopts different conformations and its protein surfaces mediate distinct protein-protein interactions in the context of different DNA sites.
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The line below this paragraph, {{ABSTRACT_PUBMED_12949493}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12949493 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12949493}}
==About this Structure==
==About this Structure==
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[[Category: Dna binding protein]]
[[Category: Dna binding protein]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:46:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:18:12 2008''

Revision as of 21:18, 28 July 2008

Image:1p7h.gif

Template:STRUCTURE 1p7h

Structure of NFAT1 bound as a dimer to the HIV-1 LTR kB element

Template:ABSTRACT PUBMED 12949493

About this Structure

1P7H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element., Giffin MJ, Stroud JC, Bates DL, von Koenig KD, Hardin J, Chen L, Nat Struct Biol. 2003 Oct;10(10):800-6. Epub 2003 Aug 31. PMID:12949493

Page seeded by OCA on Tue Jul 29 00:18:12 2008

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