1p86

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[[Image:1p86.gif|left|200px]]
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{{STRUCTURE_1p86| PDB=1p86 | SCENE= }}
{{STRUCTURE_1p86| PDB=1p86 | SCENE= }}
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'''Real space refined coordinates of the 50S subunit fitted into the low resolution cryo-EM map of the initiation-like state of E. coli 70S ribosome'''
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===Real space refined coordinates of the 50S subunit fitted into the low resolution cryo-EM map of the initiation-like state of E. coli 70S ribosome===
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==Overview==
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Cryo-EM density maps showing the 70S ribosome of E. coli in two different functional states related by a ratchet-like motion were analyzed using real-space refinement. Comparison of the two resulting atomic models shows that the ribosome changes from a compact structure to a looser one, coupled with the rearrangement of many of the proteins. Furthermore, in contrast to the unchanged inter-subunit bridges formed wholly by RNA, the bridges involving proteins undergo large conformational changes following the ratchet-like motion, suggesting an important role of ribosomal proteins in facilitating the dynamics of translation.
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(as it appears on PubMed at http://www.pubmed.gov), where 12809609 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12809609}}
==About this Structure==
==About this Structure==
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[[Category: Ratchet-like movement]]
[[Category: Ratchet-like movement]]
[[Category: Real-space refinement]]
[[Category: Real-space refinement]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:48:18 2008''
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Revision as of 19:05, 28 July 2008

Image:1p86.png

Template:STRUCTURE 1p86

Real space refined coordinates of the 50S subunit fitted into the low resolution cryo-EM map of the initiation-like state of E. coli 70S ribosome

Template:ABSTRACT PUBMED 12809609

About this Structure

1P86 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Study of the structural dynamics of the E coli 70S ribosome using real-space refinement., Gao H, Sengupta J, Valle M, Korostelev A, Eswar N, Stagg SM, Van Roey P, Agrawal RK, Harvey SC, Sali A, Chapman MS, Frank J, Cell. 2003 Jun 13;113(6):789-801. PMID:12809609

Page seeded by OCA on Mon Jul 28 22:05:16 2008

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