8c2z

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'''Unreleased structure'''
 
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The entry 8c2z is ON HOLD
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==Crystal structure of DYRK1B in complex with AZ191==
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<StructureSection load='8c2z' size='340' side='right'caption='[[8c2z]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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Authors: Grygier, P., Pustelny, K., Dubin, G., Czarna, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8c2z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C2Z FirstGlance]. <br>
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Description: Crystal structure of DYRK1B in complex with AZ191
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=QS0:N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine'>QS0</scene></td></tr>
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[[Category: Dubin, G]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c2z OCA], [https://pdbe.org/8c2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c2z RCSB], [https://www.ebi.ac.uk/pdbsum/8c2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c2z ProSAT]</span></td></tr>
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[[Category: Pustelny, K]]
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</table>
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[[Category: Grygier, P]]
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== Disease ==
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[[Category: Czarna, A]]
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[https://www.uniprot.org/uniprot/DYR1B_HUMAN DYR1B_HUMAN] NON RARE IN EUROPE: Metabolic syndrome. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/DYR1B_HUMAN DYR1B_HUMAN] Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance (PubMed:33469661). During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2 (PubMed:32611815). Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1).<ref>PMID:10910078</ref> <ref>PMID:11980910</ref> <ref>PMID:14500717</ref> <ref>PMID:24827035</ref> <ref>PMID:33469661</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Czarna A]]
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[[Category: Dubin G]]
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[[Category: Grygier P]]
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[[Category: Pustelny K]]

Revision as of 10:03, 17 January 2024

Crystal structure of DYRK1B in complex with AZ191

PDB ID 8c2z

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