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1p9d

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[[Image:1p9d.gif|left|200px]]
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[[Image:1p9d.png|left|200px]]
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{{STRUCTURE_1p9d| PDB=1p9d | SCENE= }}
{{STRUCTURE_1p9d| PDB=1p9d | SCENE= }}
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'''High-resolution structure of the complex of HHR23A ubiquitin-like domain and the C-terminal ubiquitin-interacting motif of proteasome subunit S5a'''
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===High-resolution structure of the complex of HHR23A ubiquitin-like domain and the C-terminal ubiquitin-interacting motif of proteasome subunit S5a===
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==Overview==
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HHR23A, a protein implicated in nucleotide excision repair, belongs to a class of proteins containing both a ubiquitin-like (Ubl) domain and one or more ubiquitin-associated (UBA) domains, suggesting a role in the ubiquitin-proteasome pathway as well. The Ubl domain binds with high affinity to the second ubiquitin-interacting motif (UIM) of the S5a subunit of the proteasome. Here we present the solution structures of the HHR23A Ubl domain, the second UIM of S5a (UIM-2), and the Ubl:S5a-UIM-2 complex. The HHR23A Ubl domain is structurally similar to ubiquitin. The S5a UIM forms an alpha-helix with an unexpected hairpin loop that contributes to the binding interface with Ubl. The molecular determinants of the Ubl-proteasome interaction are revealed by analysis of the structures, chemical shift mapping, mutant binding studies and sequence conservation.
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The line below this paragraph, {{ABSTRACT_PUBMED_12970176}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12970176 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12970176}}
==About this Structure==
==About this Structure==
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1P9D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9D OCA].
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1P9D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9D OCA].
==Reference==
==Reference==
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[[Category: Mueller, T D.]]
[[Category: Mueller, T D.]]
[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:50:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:48:42 2008''

Revision as of 09:48, 27 July 2008

Image:1p9d.png

Template:STRUCTURE 1p9d

High-resolution structure of the complex of HHR23A ubiquitin-like domain and the C-terminal ubiquitin-interacting motif of proteasome subunit S5a

Template:ABSTRACT PUBMED 12970176

About this Structure

1P9D is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural determinants for the binding of ubiquitin-like domains to the proteasome., Mueller TD, Feigon J, EMBO J. 2003 Sep 15;22(18):4634-45. PMID:12970176

Page seeded by OCA on Sun Jul 27 12:48:42 2008

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