8b7h
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b7h OCA], [https://pdbe.org/8b7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b7h RCSB], [https://www.ebi.ac.uk/pdbsum/8b7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b7h ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b7h OCA], [https://pdbe.org/8b7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b7h RCSB], [https://www.ebi.ac.uk/pdbsum/8b7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b7h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/GREM1_HUMAN GREM1_HUMAN] Hereditary mixed polyposis syndrome. The disease is caused by mutations affecting the gene represented in this entry. HMPS1 is caused by a duplication spanning the 3' end of the SCG5 gene and a region upstream of the GREM1 locus. This duplication is associated with increased allele-specific GREM1 expression that may cause reduced bone morphogenetic protein (BMP) pathway activity. This mechanism also underlies tumorigenesis in juvenile polyposis of the large bowel (PubMed:22561515).<ref>PMID:22561515</ref> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/GREM1_HUMAN GREM1_HUMAN] Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity).<ref>PMID:10894942</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Crystal structure of human Gremlin-1 in complex with Fab
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