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1p9y

From Proteopedia

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[[Image:1p9y.gif|left|200px]]
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{{Seed}}
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[[Image:1p9y.png|left|200px]]
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{{STRUCTURE_1p9y| PDB=1p9y | SCENE= }}
{{STRUCTURE_1p9y| PDB=1p9y | SCENE= }}
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'''Ribosome binding of E. coli Trigger Factor mutant F44L.'''
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===Ribosome binding of E. coli Trigger Factor mutant F44L.===
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==Overview==
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The exit tunnel region of the ribosome is well established as a focal point for interaction between the components that guide the fate of nascent polypeptides. One of these, the chaperone trigger factor (TF), associates with the 50S ribosomal subunit through its N-terminal domain. Targeting of TF to ribosomes is crucial to achieve its remarkable efficiency in protein folding. A similar tight coupling to translation is found in signal recognition particle (SRP)-dependent protein translocation. Here, we report crystal structures of the E. coli TF ribosome binding domain. TF is structurally related to the Hsp33 chaperone but has a prominent ribosome anchor located as a tip of the molecule. This tip includes the previously established unique TF signature motif. Comparison reveals that this feature is not found in SRP structures. We identify a conserved helical kink as a hallmark of the TF structure that is most likely critical to ensure ribosome association.
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The line below this paragraph, {{ABSTRACT_PUBMED_14656439}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14656439 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14656439}}
==About this Structure==
==About this Structure==
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[[Category: Kristensen, O.]]
[[Category: Kristensen, O.]]
[[Category: Alpha-beta protein]]
[[Category: Alpha-beta protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:52:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:27:35 2008''

Revision as of 00:27, 29 July 2008

Image:1p9y.png

Template:STRUCTURE 1p9y

Ribosome binding of E. coli Trigger Factor mutant F44L.

Template:ABSTRACT PUBMED 14656439

About this Structure

1P9Y is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Chaperone binding at the ribosomal exit tunnel., Kristensen O, Gajhede M, Structure. 2003 Dec;11(12):1547-56. PMID:14656439

Page seeded by OCA on Tue Jul 29 03:27:35 2008

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