1qyy
From Proteopedia
(New page: 200px<br /> <applet load="1qyy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qyy, resolution 2.8Å" /> '''Crystal Structure of...) |
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caption="1qyy, resolution 2.8Å" /> | caption="1qyy, resolution 2.8Å" /> | ||
'''Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 2.8 Angstrom Resolution'''<br /> | '''Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 2.8 Angstrom Resolution'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QYY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG and PT as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1QYY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=PT:'>PT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QYY OCA]. |
==Reference== | ==Reference== | ||
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[[Category: platelet receptors]] | [[Category: platelet receptors]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:46:27 2008'' |
Revision as of 14:46, 15 February 2008
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Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 2.8 Angstrom Resolution
Contents |
Overview
The interaction between platelet glycoprotein (GP) Ib alpha and von, Willebrand factor (VWF) is essential for thrombus formation, leading to, the arrest of bleeding. The N-terminal domain of GP Ib alpha, which, contains the binding sites for VWF and alpha-thrombin, crystallized in the, tetragonal space group P4(3) with one molecule in the asymmetric unit., When the crystals were treated with platinum, the crystals changed their, symmetry from tetragonal to monoclinic P2(1) with two molecules in the, asymmetric unit. The structure of the monoclinic form was solved using, two-wavelength platinum anomalous dispersion data. The tetragonal crystal, structure was subsequently solved using molecular-replacement techniques, using the monoclinic structure as the search model and was refined with, 1.7 A resolution data.
Disease
Known diseases associated with this structure: Bernard-Soulier syndrome, type A OMIM:[606672], Nonarteritic anterior ischemic optic neuropathy, susceptibility to OMIM:[606672], von Willebrand disease, platelet-type OMIM:[606672]
About this Structure
1QYY is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Platinum-induced space-group transformation in crystals of the platelet glycoprotein Ib alpha N-terminal domain., Varughese KI, Ruggeri ZM, Celikel R, Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):405-11. Epub 2004, Feb 25. PMID:14993663
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