1pau

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[[Image:1pau.gif|left|200px]]
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[[Image:1pau.png|left|200px]]
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==Overview==
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{{ABSTRACT_8673606}}
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Cysteine proteases related to mammalian interleukin-1 beta converting enzyme (ICE) and to its Caenorhabditis elegans homologue, CED-3, play a critical role in the biochemical events that culminate in apoptosis. We have determined the three-dimensional structure of a complex of the human CED-3 homologue CPP32/apopain with a potent tetrapeptide-aldehyde inhibitor. The protein resembles ICE in overall structure, but its S4 subsite is strikingly different in size and chemical composition. These differences account for the variation in specificity between the ICE- and CED-3-related proteases and enable the design of specific inhibitors that can probe the physiological functions of the proteins and disease states with which they are associated.
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==About this Structure==
==About this Structure==
1PAU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1PAU with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb56_1.html Caspases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAU OCA].
1PAU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1PAU with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb56_1.html Caspases]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAU OCA].
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==Reference==
 
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The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis., Rotonda J, Nicholson DW, Fazil KM, Gallant M, Gareau Y, Labelle M, Peterson EP, Rasper DM, Ruel R, Vaillancourt JP, Thornberry NA, Becker JW, Nat Struct Biol. 1996 Jul;3(7):619-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8673606 8673606]
 
[[Category: Caspases]]
[[Category: Caspases]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cysteine protease]]
[[Category: Cysteine protease]]
[[Category: Yama]]
[[Category: Yama]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:53:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:48:56 2008''

Revision as of 14:48, 26 June 2008

Image:1pau.png

Template:STRUCTURE 1pau

CRYSTAL STRUCTURE OF THE COMPLEX OF APOPAIN WITH THE TETRAPEPTIDE ALDEHYDE INHIBITOR AC-DEVD-CHO


Template:ABSTRACT 8673606

About this Structure

1PAU is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 1PAU with [Caspases]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:48:56 2008

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