1pax

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[[Image:1pax.gif|left|200px]]
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{{Seed}}
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[[Image:1pax.png|left|200px]]
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{{STRUCTURE_1pax| PDB=1pax | SCENE= }}
{{STRUCTURE_1pax| PDB=1pax | SCENE= }}
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'''THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH 3,4-DIHYDRO-5-METHYL-ISOQUINOLINONE'''
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===THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH 3,4-DIHYDRO-5-METHYL-ISOQUINOLINONE===
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==Overview==
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The crystal structures of the catalytic fragment of chicken poly(ADP-ribose) polymerase [NAD+ ADP-ribosyltransferase; NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyltransferase, EC 2.4.2.30] with and without a nicotinamide-analogue inhibitor have been elucidated. Because this enzyme is involved in the regulation of DNA repair, its inhibitors are of interest for cancer therapy. The inhibitor shows the nicotinamide site and also suggests the adenosine site. The enzyme is structurally related to bacterial ADP-ribosylating toxins but contains an additional alpha-helical domain that is suggested to relay the activation signal issued on binding to damaged DNA.
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The line below this paragraph, {{ABSTRACT_PUBMED_8755499}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8755499 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8755499}}
==About this Structure==
==About this Structure==
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[[Category: Glycosyltransferase]]
[[Category: Glycosyltransferase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:53:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:27:03 2008''

Revision as of 12:27, 28 July 2008

Image:1pax.png

Template:STRUCTURE 1pax

THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH 3,4-DIHYDRO-5-METHYL-ISOQUINOLINONE

Template:ABSTRACT PUBMED 8755499

About this Structure

1PAX is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken., Ruf A, Mennissier de Murcia J, de Murcia G, Schulz GE, Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7481-5. PMID:8755499

Page seeded by OCA on Mon Jul 28 15:27:03 2008

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