1pc0

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{{STRUCTURE_1pc0| PDB=1pc0 | SCENE= }}
{{STRUCTURE_1pc0| PDB=1pc0 | SCENE= }}
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'''NMR Structure of the Archaeal Homologue of RNase P Protein Rpp29'''
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===NMR Structure of the Archaeal Homologue of RNase P Protein Rpp29===
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==Overview==
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A protein component of the Archaeoglobus fulgidus RNase P was expressed in Escherichia coli, purified, and structurally characterized using multidimensional NMR methods. The dominant structural feature of this 11 kDa protein is a sheet of six antiparallel beta-strands, wrapped around a core of conserved hydrophobic amino acids. Amide proton exchange and (15)N relaxation rate data provide evidence that the first 16 residues of the protein, located before the start of the first beta-strand, and the last 24 residues, located past the end of the last beta-strand, are relatively flexible; this contrasts with the relatively rigid and well-defined structure of the beta-sheet. Amino acid sequence comparisons among a diverse set of species indicate that the A. fulgidus protein is homologous to the human RNase P protein Rpp29, yeast RNase P protein Pop4, and a known archaeal RNase P protein from Methanobacter thermoautotrophicus; conserved hydrophobic residues indicate that the homologous protein in each of these species contains a similar beta-sheet structure. Conserved surface residues located in the loop connecting strands beta2 and beta3, the loop connecting strands beta4 and beta5, and in the flexible N- and C-terminal tails are most likely to have specific interactions with the RNA and other proteins of RNase P. The structural model of an RNase P protein component provided by the present work provides an essential step toward eventually understanding the overall architecture of this complex enzyme and the mechanism by which it performs its functions.
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{{ABSTRACT_PUBMED_14622001}}
==About this Structure==
==About this Structure==
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1PC0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PC0 OCA].
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1PC0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PC0 OCA].
==Reference==
==Reference==
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[[Category: Beta-sheet]]
[[Category: Beta-sheet]]
[[Category: Sandwich]]
[[Category: Sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:55:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:02:24 2008''

Revision as of 17:02, 28 July 2008

Image:1pc0.png

Template:STRUCTURE 1pc0

NMR Structure of the Archaeal Homologue of RNase P Protein Rpp29

Template:ABSTRACT PUBMED 14622001

About this Structure

1PC0 is a Single protein structure of sequence from Archaeoglobus fulgidus. Full experimental information is available from OCA.

Reference

NMR structure of an archaeal homologue of ribonuclease P protein Rpp29., Sidote DJ, Hoffman DW, Biochemistry. 2003 Nov 25;42(46):13541-50. PMID:14622001

Page seeded by OCA on Mon Jul 28 20:02:24 2008

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