This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1pc9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1pc9.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1pc9.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1pc9| PDB=1pc9 | SCENE= }}
{{STRUCTURE_1pc9| PDB=1pc9 | SCENE= }}
-
'''Crystal Structure of BnSP-6, a Lys49-Phospholipase A2'''
+
===Crystal Structure of BnSP-6, a Lys49-Phospholipase A2===
-
==Overview==
+
<!--
-
Phospholipases A(2) are components of Bothrops venoms responsible for disruption of cell membrane integrity via hydrolysis of its phospholipids. A class of PLA(2)-like proteins has been described which despite PLA(2) activity on artificial substrate, due to a D49K mutation, is still highly myonecrotic. This work reports the X-ray structure determination of two Lys49-PLA(2)s from Bothrops neuwiedi pauloensis (BnSP-7 and BnSP-6) and, for the first time, the comparison of eight dimeric Lys49-PLA(2)s. This comparison reveals that there are not just two ("open" and "closed") but at least six different conformations. The binding of fatty acid observed in three recent Lys49-PLA(2) structures seems to be independent of their quaternary conformation. Cys29 polarization by Lys122 is not significant for BnSP-7 and BnSP-6 or other structures not bound by fatty acids. These structures may be in an "active" state when nothing is bound to them and the Lys122/Cys29 interactions are weak or absent.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14623331}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14623331 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14623331}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Myotoxin]]
[[Category: Myotoxin]]
[[Category: Venom.]]
[[Category: Venom.]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:55:53 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:29:10 2008''

Revision as of 04:29, 28 July 2008

Image:1pc9.png

Template:STRUCTURE 1pc9

Crystal Structure of BnSP-6, a Lys49-Phospholipase A2

Template:ABSTRACT PUBMED 14623331

About this Structure

1PC9 is a Single protein structure of sequence from Bothrops neuwiedi pauloensis. Full crystallographic information is available from OCA.

Reference

Crystal structures of BnSP-7 and BnSP-6, two Lys49-phospholipases A(2): quaternary structure and inhibition mechanism insights., Magro AJ, Soares AM, Giglio JR, Fontes MR, Biochem Biophys Res Commun. 2003 Nov 21;311(3):713-20. PMID:14623331

Page seeded by OCA on Mon Jul 28 07:29:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pc9"
Personal tools