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1pe0

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[[Image:1pe0.gif|left|200px]]
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{{STRUCTURE_1pe0| PDB=1pe0 | SCENE= }}
{{STRUCTURE_1pe0| PDB=1pe0 | SCENE= }}
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'''Crystal structure of the K130R mutant of human DJ-1'''
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===Crystal structure of the K130R mutant of human DJ-1===
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==Overview==
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We report the crystal structure at 1.8-A resolution of human DJ-1, which has been linked to early onset Parkinson's disease. The monomer of DJ-1 contains the alpha/beta-fold that is conserved among members of the DJ-1/ThiJ/PfpI superfamily. However, the structure also contains an extra helix at the C terminus, which mediates a novel mode of dimerization for the DJ-1 proteins. A putative active site has been identified near the dimer interface, and the residues Cys-106, His-126, and Glu-18 may play important roles in the catalysis by this protein. Studies with the disease-causing L166P mutant suggest that the mutation has disrupted the C-terminal region and the dimerization of the protein. The DJ-1 proteins may function only as dimers. The Lys to Arg mutation at residue 130, the site of sumoylation of DJ-1, has minimal impact on the structure of the protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 12761214 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12761214}}
==About this Structure==
==About this Structure==
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[[Category: Tong, L.]]
[[Category: Tong, L.]]
[[Category: Dj-1]]
[[Category: Dj-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:58:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:56:37 2008''

Revision as of 11:56, 28 July 2008

Image:1pe0.png

Template:STRUCTURE 1pe0

Crystal structure of the K130R mutant of human DJ-1

Template:ABSTRACT PUBMED 12761214

About this Structure

1PE0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease., Tao X, Tong L, J Biol Chem. 2003 Aug 15;278(33):31372-9. Epub 2003 May 21. PMID:12761214

Page seeded by OCA on Mon Jul 28 14:56:37 2008

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