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1pen

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{{STRUCTURE_1pen| PDB=1pen | SCENE= }}
{{STRUCTURE_1pen| PDB=1pen | SCENE= }}
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'''ALPHA-CONOTOXIN PNI1'''
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===ALPHA-CONOTOXIN PNI1===
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==Overview==
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BACKGROUND: alpha-Conotoxins are peptide toxins, isolated from Conus snails, that block the nicotinic acetylcholine receptor (nAChR). The 16-residue peptides PnIA and PnIB from Conus pennaceus incorporate the same disulfide framework as other alpha-conotoxins but differ in function from most alpha-conotoxins by blocking the neuronal nAChR, rather than the skeletal muscle subtype. The crystal structure determination of PnIA was undertaken to identify structural and surface features that might be important for biological activity. RESULTS: The 1.1 A crystal structure of synthetic PnIA was determined by direct methods using the Shake-and-Bake program. The three-dimensional structure incorporates a beta turn followed by two alpha-helical turns. The conformation is stabilised by two disulfide bridges that form the interior of the molecule, with all other side chains oriented outwards. CONCLUSIONS: The compact architecture of the PnIA toxin provides a rigid framework for presentation of chemical groups that are required for activity. The structure is characterized by distinct hydrophobic and polar surfaces; a 16 A separation of the sole positive and negative charges (these two charged residues being located at opposite ends of the molecule); a hydrophobic region and a protruding tyrosine side chain. These features may be important for the specific interaction of PnIA with neuronal nAChR.
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(as it appears on PubMed at http://www.pubmed.gov), where 8740364 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8740364}}
==About this Structure==
==About this Structure==
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[[Category: Neurotoxin]]
[[Category: Neurotoxin]]
[[Category: Postsynaptic]]
[[Category: Postsynaptic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:07:21 2008''

Revision as of 09:07, 29 July 2008

Image:1pen.png

Template:STRUCTURE 1pen

ALPHA-CONOTOXIN PNI1

Template:ABSTRACT PUBMED 8740364

About this Structure

1PEN is a Single protein structure of sequence from Conus pennaceus. Full crystallographic information is available from OCA.

Reference

The 1.1 A crystal structure of the neuronal acetylcholine receptor antagonist, alpha-conotoxin PnIA from Conus pennaceus., Hu SH, Gehrmann J, Guddat LW, Alewood PF, Craik DJ, Martin JL, Structure. 1996 Apr 15;4(4):417-23. PMID:8740364

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