8xmo

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m (Protected "8xmo" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8xmo is ON HOLD
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==Voltage-gated sodium channel Nav1.7 variant M4==
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<StructureSection load='8xmo' size='340' side='right'caption='[[8xmo]], [[Resolution|resolution]] 3.39&Aring;' scene=''>
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Authors: Yan, N., Li, Z., Wu, Q., Huang, G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8xmo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XMO FirstGlance]. <br>
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Description: Voltage-gated sodium channel Nav1.7 variant M4
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.39&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LPE:1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>LPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene></td></tr>
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[[Category: Yan, N]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xmo OCA], [https://pdbe.org/8xmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xmo RCSB], [https://www.ebi.ac.uk/pdbsum/8xmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xmo ProSAT]</span></td></tr>
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[[Category: Huang, G]]
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</table>
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[[Category: Li, Z]]
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== Disease ==
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[[Category: Wu, Q]]
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[https://www.uniprot.org/uniprot/SCN2B_HUMAN SCN2B_HUMAN] Familial atrial fibrillation. The disease is caused by mutations affecting the gene represented in this entry. Genetic variations in SCN2B may be involved in Brugada syndrome (PubMed:23559163). This tachyarrhythmia is characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.<ref>PMID:23559163</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/SCN2B_HUMAN SCN2B_HUMAN] Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Huang G]]
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[[Category: Li Z]]
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[[Category: Wu Q]]
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[[Category: Yan N]]

Revision as of 12:12, 6 March 2024

Voltage-gated sodium channel Nav1.7 variant M4

PDB ID 8xmo

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