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7gtm
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA Analysis group deposition -- Crystal structure of PTP1B in complex with FMOOA000543a== | |
| - | + | <StructureSection load='7gtm' size='340' side='right'caption='[[7gtm]], [[Resolution|resolution]] 1.72Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7gtm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7GTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7GTM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ABV:(4S)-4-hydroxy-2-(propan-2-yl)-3,4-dihydro-1lambda~6~,2-benzothiazine-1,1(2H)-dione'>A1ABV</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7gtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7gtm OCA], [https://pdbe.org/7gtm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7gtm RCSB], [https://www.ebi.ac.uk/pdbsum/7gtm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7gtm ProSAT]</span></td></tr> |
| - | [[Category: Ginn | + | </table> |
| - | [[Category: Keedy | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ginn HM]] | ||
| + | [[Category: Keedy DA]] | ||
| + | [[Category: Mehlman T]] | ||
Current revision
PanDDA Analysis group deposition -- Crystal structure of PTP1B in complex with FMOOA000543a
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