8j6j

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Current revision (06:52, 3 July 2025) (edit) (undo)
 
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<table><tr><td colspan='2'>[[8j6j]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J6J FirstGlance]. <br>
<table><tr><td colspan='2'>[[8j6j]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J6J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J6J FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OKL:8-chloranyl-3-pentyl-7H-purine-2,6-dione'>OKL</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OKL:8-chloranyl-3-pentyl-7~{H}-purine-2,6-dione'>OKL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j6j OCA], [https://pdbe.org/8j6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j6j RCSB], [https://www.ebi.ac.uk/pdbsum/8j6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j6j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j6j OCA], [https://pdbe.org/8j6j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j6j RCSB], [https://www.ebi.ac.uk/pdbsum/8j6j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j6j ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
 
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Current revision

Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound with GSK256073

PDB ID 8j6j

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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