1r55
From Proteopedia
(New page: 200px<br /> <applet load="1r55" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r55, resolution 1.58Å" /> '''Crystal structure o...) |
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| - | [[Image:1r55. | + | [[Image:1r55.jpg|left|200px]]<br /><applet load="1r55" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1r55, resolution 1.58Å" /> | caption="1r55, resolution 1.58Å" /> | ||
'''Crystal structure of the catalytic domain of human ADAM 33'''<br /> | '''Crystal structure of the catalytic domain of human ADAM 33'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1R55 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, CA, CL and 097 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1R55 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=097:'>097</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R55 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: metalloprotease]] | [[Category: metalloprotease]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:47:00 2008'' |
Revision as of 14:47, 15 February 2008
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Crystal structure of the catalytic domain of human ADAM 33
Overview
Adam33 is a putative asthma susceptibility gene encoding for a, membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs, (a disintegrin and metalloprotease) are a family of glycoproteins, implicated in cell-cell interactions, cell fusion, and cell signaling. We, have determined the crystal structure of the Adam33 catalytic domain in, complex with the inhibitor marimastat and the inhibitor-free form. The, structures reveal the polypeptide fold and active site environment, resembling that of other metalloproteases. The substrate-binding site, contains unique features that allow the structure-based design of specific, inhibitors of this enzyme.
About this Structure
1R55 is a Single protein structure of sequence from Homo sapiens with , , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the catalytic domain of human ADAM33., Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V, J Mol Biol. 2004 Jan 2;335(1):129-37. PMID:14659745
Page seeded by OCA on Fri Feb 15 16:47:00 2008
Categories: Homo sapiens | Single protein | Hammond, G. | Le, H.V. | Madison, V. | Mirza, U.A. | Orth, P. | Prosise, W.W. | Reichert, P. | Strickland, C. | Taremi, S.S. | Wang, W. | Xiao, L. | Yarosh-Tomaine, T. | Zou, J. | 097 | CA | CL | ZN | Adam | Asthma | Inhibitor | Metalloprotease
