This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1phr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1phr.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1phr.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1phr| PDB=1phr | SCENE= }}
{{STRUCTURE_1phr| PDB=1phr | SCENE= }}
-
'''THE CRYSTAL STRUCTURE OF A LOW MOLECULAR PHOSPHOTYROSINE PROTEIN PHOSPHATASE'''
+
===THE CRYSTAL STRUCTURE OF A LOW MOLECULAR PHOSPHOTYROSINE PROTEIN PHOSPHATASE===
-
==Overview==
+
<!--
-
Protein tyrosine phosphorylation and dephosphorylation are central reactions for control of cellular division, differentiation and development. Here we describe the crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase (PTPase), a cytosolic phosphatase present in many mammalian cells. The enzyme catalyses the dephosphorylation of phosphotyrosine-containing substrates, and overexpression of the protein in normal and transformed cells inhibits cell proliferation. The structure of the low-molecular-weight PTPase reveals an alpha/beta protein containing a phosphate-binding loop motif at the amino end of helix alpha 1. This motif includes the essential active-site residues Cys 12 and Arg 18 and bears striking similarities to the active-site motif recently described in the structure of human PTP1B. The structure of the low-molecular-weight PTPase supports a reaction mechanism involving the conserved Cys 12 as an attacking nucleophile in an in-line associative mechanism. The structure also suggests a catalytic role for Asp 129 in the reaction cycle.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8052313}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8052313 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8052313}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Taddei, N.]]
[[Category: Taddei, N.]]
[[Category: Phosphotyrosine protein phosphatase]]
[[Category: Phosphotyrosine protein phosphatase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:06:01 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:54:42 2008''

Revision as of 08:54, 29 July 2008

Image:1phr.png

Template:STRUCTURE 1phr

THE CRYSTAL STRUCTURE OF A LOW MOLECULAR PHOSPHOTYROSINE PROTEIN PHOSPHATASE

Template:ABSTRACT PUBMED 8052313

About this Structure

1PHR is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase., Su XD, Taddei N, Stefani M, Ramponi G, Nordlund P, Nature. 1994 Aug 18;370(6490):575-8. PMID:8052313

Page seeded by OCA on Tue Jul 29 11:54:42 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1phr"
Personal tools