1pjc

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[[Image:1pjc.gif|left|200px]]
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{{STRUCTURE_1pjc| PDB=1pjc | SCENE= }}
{{STRUCTURE_1pjc| PDB=1pjc | SCENE= }}
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'''L-ALANINE DEHYDROGENASE COMPLEXED WITH NAD'''
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===L-ALANINE DEHYDROGENASE COMPLEXED WITH NAD===
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==Overview==
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The structure of the hexameric L-alanine dehydrogenase from Phormidium lapideum reveals that the subunit is constructed from two domains, each having the common dinucleotide binding fold. Despite there being no sequence similarity, the fold of alanine dehydrogenase is closely related to that of the family of D-2-hydroxyacid dehydrogenases, with a similar location of the active site, suggesting that these enzymes are related by divergent evolution. L-alanine dehydrogenase and the 2-hydroxyacid dehydrogenases also use equivalent functional groups to promote substrate recognition and catalysis. However, they are arranged differently on the enzyme surface, which has the effect of directing opposite faces of the keto acid to the dinucleotide in each case, forcing a change in absolute configuration of the product.
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(as it appears on PubMed at http://www.pubmed.gov), where 9665169 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9665169}}
==About this Structure==
==About this Structure==
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[[Category: Nad]]
[[Category: Nad]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:08:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:40:35 2008''

Revision as of 05:40, 28 July 2008

Image:1pjc.png

Template:STRUCTURE 1pjc

L-ALANINE DEHYDROGENASE COMPLEXED WITH NAD

Template:ABSTRACT PUBMED 9665169

About this Structure

1PJC is a Single protein structure of sequence from Phormidium lapideum. Full crystallographic information is available from OCA.

Reference

Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase., Baker PJ, Sawa Y, Shibata H, Sedelnikova SE, Rice DW, Nat Struct Biol. 1998 Jul;5(7):561-7. PMID:9665169

Page seeded by OCA on Mon Jul 28 08:40:35 2008

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