We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1pko

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1pko.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1pko.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1pko| PDB=1pko | SCENE= }}
{{STRUCTURE_1pko| PDB=1pko | SCENE= }}
-
'''Myelin Oligodendrocyte Glycoprotein (MOG)'''
+
===Myelin Oligodendrocyte Glycoprotein (MOG)===
-
==Overview==
+
<!--
-
Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and axonal loss. The immunopathogenesis of demyelination in multiple sclerosis involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG), a type I transmembrane protein located at the surface of CNS myelin. Here we present the crystal structures of the extracellular domain of MOG (MOGIgd) at 1.45-A resolution and the complex of MOGIgd with the antigen-binding fragment (Fab) of the MOG-specific demyelinating monoclonal antibody 8-18C5 at 3.0-A resolution. MOGIgd adopts an IgV like fold with the A'GFCC'C" sheet harboring a cavity similar to the one used by the costimulatory molecule B7-2 to bind its ligand CTLA4. The antibody 8-18C5 binds to three loops located at the membrane-distal side of MOG with a surprisingly dominant contribution made by MOG residues 101-108 containing a strained loop that forms the upper edge of the putative ligand binding site. The sequence R101DHSYQEE108 is unique for MOG, whereas large parts of the remaining sequence are conserved in potentially tolerogenic MOG homologues expressed outside the immuno-privileged environment of the CNS. Strikingly, the only sequence identical to DHSYQEE was found in a Chlamydia trachomatis protein of unknown function, raising the possibility that Chlamydia infections may play a role in the MOG-specific autoimmune response in man. Our data provide the structural basis for the development of diagnostic and therapeutic strategies targeting the pathogenic autoantibody response to MOG.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12874380}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12874380 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12874380}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Zander, H.]]
[[Category: Zander, H.]]
[[Category: Igv-domain]]
[[Category: Igv-domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:11:40 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:31:07 2008''

Revision as of 22:31, 28 July 2008

Image:1pko.png

Template:STRUCTURE 1pko

Myelin Oligodendrocyte Glycoprotein (MOG)

Template:ABSTRACT PUBMED 12874380

About this Structure

1PKO is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein., Breithaupt C, Schubart A, Zander H, Skerra A, Huber R, Linington C, Jacob U, Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9446-51. Epub 2003 Jul 21. PMID:12874380

Page seeded by OCA on Tue Jul 29 01:31:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pko"
Personal tools