1pkp

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[[Image:1pkp.gif|left|200px]]
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{{STRUCTURE_1pkp| PDB=1pkp | SCENE= }}
{{STRUCTURE_1pkp| PDB=1pkp | SCENE= }}
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'''THE STRUCTURE OF RIBOSOMAL PROTEIN S5 REVEALS SITES OF INTERACTION WITH 16S RRNA'''
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===THE STRUCTURE OF RIBOSOMAL PROTEIN S5 REVEALS SITES OF INTERACTION WITH 16S RRNA===
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==Overview==
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Understanding the process whereby the ribosome translates the genetic code into protein molecules will ultimately require high-resolution structural information, and we report here the first crystal structure of a protein from the small ribosomal subunit. This protein, S5, has a molecular mass of 17,500 and is highly conserved in all lifeforms. The molecule contains two distinct alpha/beta domains that have structural similarities to several other proteins that are components of ribonucleoprotein complexes. Mutations in S5 result in several phenotypes which suggest that S5 may have a role in translational fidelity and translocation. These include ribosome ambiguity or ram, reversion from streptomycin dependence and resistance to spectinomycin. Also, a cold-sensitive, spectinomycin-resistant mutant of S5 has been identified which is defective in initiation. Here we show that these mutations map to two distinct regions of the molecule which seem to be sites of interaction with ribosomal RNA. A structure/function analysis of the molecule reveals discrepancies with current models of the 30S subunit.
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The line below this paragraph, {{ABSTRACT_PUBMED_1508272}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1508272 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1508272}}
==About this Structure==
==About this Structure==
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[[Category: White, S W.]]
[[Category: White, S W.]]
[[Category: Ribosomal protein]]
[[Category: Ribosomal protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:11:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:31:04 2008''

Revision as of 16:31, 28 July 2008

Image:1pkp.png

Template:STRUCTURE 1pkp

THE STRUCTURE OF RIBOSOMAL PROTEIN S5 REVEALS SITES OF INTERACTION WITH 16S RRNA

Template:ABSTRACT PUBMED 1508272

About this Structure

1PKP is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

The structure of ribosomal protein S5 reveals sites of interaction with 16S rRNA., Ramakrishnan V, White SW, Nature. 1992 Aug 27;358(6389):768-71. PMID:1508272

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