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Calcipotriol
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In mouse studies, topical calcipotriol administration to the ear and dorsal skin led to a dose-dependent increase in the production of the epithelial cell-derived cytokine TSLP by keratinocytes, and triggered atopic dermatitis at high concentrations.<ref name="a10">PMID:16880407</ref> This upregulation of TSLP production due to calcipotriol application is thought to be mediated through the coactivation of [[vitamin D receptor]]/[[Retinoid X receptor]] α and [[vitamin D receptor]]/[[Retinoid X receptor]] β heterodimers. | In mouse studies, topical calcipotriol administration to the ear and dorsal skin led to a dose-dependent increase in the production of the epithelial cell-derived cytokine TSLP by keratinocytes, and triggered atopic dermatitis at high concentrations.<ref name="a10">PMID:16880407</ref> This upregulation of TSLP production due to calcipotriol application is thought to be mediated through the coactivation of [[vitamin D receptor]]/[[Retinoid X receptor]] α and [[vitamin D receptor]]/[[Retinoid X receptor]] β heterodimers. | ||
| - | [[1s19]]. | + | <scene name='10/1023614/Cv/2'>VDR ligand binding domain complexed to calcipotriol</scene> ([[1s19]]). |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 13:21, 22 January 2024
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References
- ↑ Li M, Hener P, Zhang Z, Kato S, Metzger D, Chambon P. Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11736-41. PMID:16880407 doi:10.1073/pnas.0604575103
