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8rq4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-em structure of the rat Multidrug resistance-associated protein 2 (rMrp2) in complex with probenecid== | |
| - | + | <StructureSection load='8rq4' size='340' side='right'caption='[[8rq4]], [[Resolution|resolution]] 3.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8rq4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RQ4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.45Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RTO:4-(dipropylsulfamoyl)benzoic+acid'>RTO</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rq4 OCA], [https://pdbe.org/8rq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rq4 RCSB], [https://www.ebi.ac.uk/pdbsum/8rq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rq4 ProSAT]</span></td></tr> |
| - | [[Category: Beis | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/MRP2_RAT MRP2_RAT] Defects in Abcc2 are a cause of hereditary conjugated hyperbilirubinemia (EHBR).<ref>PMID:8599091</ref> [REFERENCE:3] | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MRP2_RAT MRP2_RAT] ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:8662992, PubMed:10421658, PubMed:10220572, PubMed:11248200). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:10220572, PubMed:8662992). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:11248200). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (By similarity).[UniProtKB:Q92887]<ref>PMID:10220572</ref> <ref>PMID:10421658</ref> <ref>PMID:11248200</ref> <ref>PMID:8662992</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Beis K]] | ||
| + | [[Category: Mazza T]] | ||
Current revision
Cryo-em structure of the rat Multidrug resistance-associated protein 2 (rMrp2) in complex with probenecid
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