1pls

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[[Image:1pls.gif|left|200px]]
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{{STRUCTURE_1pls| PDB=1pls | SCENE= }}
{{STRUCTURE_1pls| PDB=1pls | SCENE= }}
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'''SOLUTION STRUCTURE OF A PLECKSTRIN HOMOLOGY DOMAIN'''
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===SOLUTION STRUCTURE OF A PLECKSTRIN HOMOLOGY DOMAIN===
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==Overview==
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Pleckstrin, the major protein kinase C substrate of platelets, contains domains of about 100 amino acids at the amino and carboxy termini that have been found in a number of proteins, including serine/threonine kinases, GTPase-activating proteins, phospholipases and cytoskeletal proteins. These conserved sequences, termed pleckstrin-homology (PH) domains, are thought to be involved in signal transduction. But the details of the function and binding partners of the PH domains have not been characterized. Here we report the solution structure of the N-terminal pleckstrin-homology domain of pleckstrin determined using heteronuclear three-dimensional nuclear magnetic resonance spectroscopy. The structure consists of an up-and-down beta-barrel of seven antiparallel beta-strands and a C-terminal amphiphilic alpha-helix that caps one end of the barrel. The overall topology of the domain is similar to that of the retinol-binding protein family of structures.
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{{ABSTRACT_PUBMED_8208296}}
==About this Structure==
==About this Structure==
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1PLS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PLS OCA].
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1PLS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PLS OCA].
==Reference==
==Reference==
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[[Category: Yoon, H S.]]
[[Category: Yoon, H S.]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:13:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:23:07 2008''

Revision as of 07:23, 28 July 2008

Image:1pls.png

Template:STRUCTURE 1pls

SOLUTION STRUCTURE OF A PLECKSTRIN HOMOLOGY DOMAIN

Template:ABSTRACT PUBMED 8208296

About this Structure

1PLS is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of a pleckstrin-homology domain., Yoon HS, Hajduk PJ, Petros AM, Olejniczak ET, Meadows RP, Fesik SW, Nature. 1994 Jun 23;369(6482):672-5. PMID:8208296

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