1pm4

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{{STRUCTURE_1pm4| PDB=1pm4 | SCENE= }}
{{STRUCTURE_1pm4| PDB=1pm4 | SCENE= }}
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'''Crystal structure of Yersinia pseudotuberculosis-derived mitogen (YPM)'''
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===Crystal structure of Yersinia pseudotuberculosis-derived mitogen (YPM)===
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==Overview==
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Superantigens are a class of microbial proteins with the ability to excessively activate T cells by binding to the T cell receptor. The staphylococcal and streptococcal superantigens are closely related in structure and possess an N-terminal domain that resembles an OB fold and a C-terminal domain similar to a beta-grasp fold. Yersinia pseudotuberculosis produces superantigens, YPMa, YPMb, and YPMc, which have no significant amino acid similarity to other proteins. We have determined the crystal and solution structures of YPMa, which show that the protein has a jelly-roll fold. The closest structural neighbors to YPMa are viral capsid proteins and members of the tumor necrosis factor superfamily. In the crystal structure, YPMa packs as a trimer, another feature shared with viral capsid proteins and TNF superfamily proteins. However, in solution YPMa behaves as a monomer, and any functional relevance of the trimer observed in the crystals is yet to be established.
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(as it appears on PubMed at http://www.pubmed.gov), where 14725774 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14725774}}
==About this Structure==
==About this Structure==
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[[Category: Mackay, J P.]]
[[Category: Mackay, J P.]]
[[Category: Jelly roll fold]]
[[Category: Jelly roll fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:14:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:52:58 2008''

Revision as of 17:53, 28 July 2008

Image:1pm4.png

Template:STRUCTURE 1pm4

Crystal structure of Yersinia pseudotuberculosis-derived mitogen (YPM)

Template:ABSTRACT PUBMED 14725774

About this Structure

1PM4 is a Single protein structure of sequence from Yersinia pseudotuberculosis. Full crystallographic information is available from OCA.

Reference

Crystal and solution structures of a superantigen from Yersinia pseudotuberculosis reveal a jelly-roll fold., Donadini R, Liew CW, Kwan AH, Mackay JP, Fields BA, Structure. 2004 Jan;12(1):145-56. PMID:14725774

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