This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1pmn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1pmn.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1pmn.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1pmn| PDB=1pmn | SCENE= }}
{{STRUCTURE_1pmn| PDB=1pmn | SCENE= }}
-
'''Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor'''
+
===Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor===
-
==Overview==
+
<!--
-
The c-Jun terminal kinases (JNKs) are members of the mitogen-activated protein (MAP) kinase family and regulate signal transduction in response to environmental stress. Activation of JNK3, a neuronal-specific isoform, has been associated with neurological damage, and as such, JNK3 may represent an attractive target for the treatment of neurological disorders. The MAP kinases share between 50% and 80% sequence identity. In order to obtain efficacious and safe compounds, it is necessary to address the issues of potency and selectivity. We report here four crystal structures of JNK3 in complex with three different classes of inhibitors. These structures provide a clear picture of the interactions that each class of compound made with the kinase. Knowledge of the atomic interactions involved in these diverse binding modes provides a platform for structure-guided modification of these compounds, or the de novo design of novel inhibitors that could satisfy the need for potency and selectivity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12954329}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12954329 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12954329}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Inhibition]]
[[Category: Inhibition]]
[[Category: Map kinase]]
[[Category: Map kinase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:15:19 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:52:30 2008''

Revision as of 10:52, 28 July 2008

Image:1pmn.png

Template:STRUCTURE 1pmn

Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor

Template:ABSTRACT PUBMED 12954329

About this Structure

1PMN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity., Scapin G, Patel SB, Lisnock J, Becker JW, LoGrasso PV, Chem Biol. 2003 Aug;10(8):705-12. PMID:12954329

Page seeded by OCA on Mon Jul 28 13:52:30 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pmn"
Personal tools