1pn5

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{{STRUCTURE_1pn5| PDB=1pn5 | SCENE= }}
{{STRUCTURE_1pn5| PDB=1pn5 | SCENE= }}
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'''NMR structure of the NALP1 Pyrin domain (PYD)'''
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===NMR structure of the NALP1 Pyrin domain (PYD)===
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==Overview==
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Signaling in apoptosis and inflammation is often mediated by proteins of the death domain superfamily in the Fas/FADD/Caspase-8 or the Apaf-1/Caspase-9 pathways. This superfamily currently comprises the death domain (DD), death effector domain (DED), caspase recruitment domain (CARD), and pyrin domain (PYD) subfamilies. The PYD subfamily is most abundant, but three-dimensional structures are only available for the subfamilies DD, DED, and CARD, which have an antiparallel arrangement of six alpha helices as common fold. This paper presents the NMR structure of PYD of NALP1, a protein that is involved in the innate immune response and is a component of the inflammasome. The structure of NALP1 PYD differs from all other known death domain superfamily structures in that the third alpha helix is replaced by a flexibly disordered loop. This unique feature appears to relate to the molecular basis of familial Mediterranean fever (FMF), a genetic disease caused by single-point mutations.
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{{ABSTRACT_PUBMED_14527388}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1PN5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN5 OCA].
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1PN5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN5 OCA].
==Reference==
==Reference==
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[[Category: Wuthrich, K.]]
[[Category: Wuthrich, K.]]
[[Category: 5 alpha-helix bundle]]
[[Category: 5 alpha-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:16:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:48:08 2008''

Revision as of 17:48, 27 July 2008

Image:1pn5.png

Template:STRUCTURE 1pn5

Contents

NMR structure of the NALP1 Pyrin domain (PYD)

Template:ABSTRACT PUBMED 14527388

Disease

Known disease associated with this structure: Vitiligo-associated multiple autoimmune disease susceptibility 1 OMIM:[606636]

About this Structure

1PN5 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain., Hiller S, Kohl A, Fiorito F, Herrmann T, Wider G, Tschopp J, Grutter MG, Wuthrich K, Structure. 2003 Oct;11(10):1199-205. PMID:14527388

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