We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1pny

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1pny.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1pny.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1pny| PDB=1pny | SCENE= }}
{{STRUCTURE_1pny| PDB=1pny | SCENE= }}
-
'''Crystal Structure of the Wild Type Ribosome from E. Coli, 50S Subunit of 70S Ribosome. THIS FILE, 1PNY, CONTAINS ONLY MOLECULES OF THE 50S RIBOSOMAL SUBUNIT. THE 30S SUBUNIT IS IN THE PDB FILE 1PNX.'''
+
===Crystal Structure of the Wild Type Ribosome from E. Coli, 50S Subunit of 70S Ribosome. THIS FILE, 1PNY, CONTAINS ONLY MOLECULES OF THE 50S RIBOSOMAL SUBUNIT. THE 30S SUBUNIT IS IN THE PDB FILE 1PNX.===
-
==Overview==
+
<!--
-
Protein biosynthesis on the ribosome requires accurate reading of the genetic code in mRNA. Two conformational rearrangements in the small ribosomal subunit, a closing of the head and body around the incoming tRNA and an RNA helical switch near the mRNA decoding site, have been proposed to select for complementary base-pairing between mRNA codons and tRNA anticodons. We determined x-ray crystal structures of the WT and a hyper-accurate variant of the Escherichia coli ribosome at resolutions of 10 and 9 A, respectively, revealing that formation of the intact 70S ribosome from its two subunits closes the conformation of the head of the small subunit independent of mRNA decoding. Moreover, no change in the conformation of the switch helix is observed in two steps of tRNA discrimination. These 70S ribosome structures indicate that mRNA decoding is coupled primarily to movement of the small subunit body, consistent with previous proposals, whereas closing of the head and the helical switch may function in other steps of protein synthesis.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12853578}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12853578 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12853578}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Protein-rna complex]]
[[Category: Protein-rna complex]]
[[Category: Rna-rna complex]]
[[Category: Rna-rna complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:17:32 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:45:53 2008''

Revision as of 16:45, 28 July 2008

Image:1pny.png

Template:STRUCTURE 1pny

Crystal Structure of the Wild Type Ribosome from E. Coli, 50S Subunit of 70S Ribosome. THIS FILE, 1PNY, CONTAINS ONLY MOLECULES OF THE 50S RIBOSOMAL SUBUNIT. THE 30S SUBUNIT IS IN THE PDB FILE 1PNX.

Template:ABSTRACT PUBMED 12853578

About this Structure

Full crystallographic information is available from OCA.

Reference

X-ray crystal structures of the WT and a hyper-accurate ribosome from Escherichia coli., Vila-Sanjurjo A, Ridgeway WK, Seymaner V, Zhang W, Santoso S, Yu K, Cate JH, Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8682-7. Epub 2003 Jul 9. PMID:12853578

Page seeded by OCA on Mon Jul 28 19:45:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pny"
Personal tools