1poc

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[[Image:1poc.gif|left|200px]]
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{{STRUCTURE_1poc| PDB=1poc | SCENE= }}
{{STRUCTURE_1poc| PDB=1poc | SCENE= }}
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'''CRYSTAL STRUCTURE OF BEE-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE'''
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===CRYSTAL STRUCTURE OF BEE-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE===
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==Overview==
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The 2.0 angstroms crystal structure of a complex containing bee-venom phospholipase A2 (PLA2) and a phosphonate transition-state analogue was solved by multiple isomorphous replacement. The electron-density map is sufficiently detailed to visualize the proximal sugars of the enzyme's N-linked carbohydrate and a single molecule of the transition-state analogue bound ot its active center. Although bee-venom PLA2 does not belong to the large homologous Class I/II family that encompasses most other well-studied PLA2s, there is segmental sequence similarity and conservation of many functional substructures. Comparison of the bee-venom enzyme with other phospholipase structures provides compelling evidence for a common catalytic mechanism.
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The line below this paragraph, {{ABSTRACT_PUBMED_2274788}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 2274788 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2274788}}
==About this Structure==
==About this Structure==
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[[Category: Sigler, P B.]]
[[Category: Sigler, P B.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:18:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:55:40 2008''

Revision as of 08:55, 29 July 2008

Image:1poc.png

Template:STRUCTURE 1poc

CRYSTAL STRUCTURE OF BEE-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE

Template:ABSTRACT PUBMED 2274788

About this Structure

1POC is a Single protein structure of sequence from Apis mellifera. Full crystallographic information is available from OCA.

Reference

Crystal structure of bee-venom phospholipase A2 in a complex with a transition-state analogue., Scott DL, Otwinowski Z, Gelb MH, Sigler PB, Science. 1990 Dec 14;250(4987):1563-6. PMID:2274788

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