1pop

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[[Image:1pop.gif|left|200px]]
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{{STRUCTURE_1pop| PDB=1pop | SCENE= }}
{{STRUCTURE_1pop| PDB=1pop | SCENE= }}
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'''X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX'''
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===X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX===
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==Overview==
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The three-dimensional structure of the papain-leupeptin complex has been determined by X-ray crystallography to a resolution of 2.1 A (overall R-factor = 19.8%). The structure indicates that: (i) leupeptin contacts the S subsites of the papain active site and not the S' subsites; (ii) the 'carbonyl' carbon atom of the inhibitor is covalently bound by the Cys-25 sulphur atom of papain and is tetrahedrally coordinated; (iii) the 'carbonyl' oxygen atom of the inhibitor faces the oxyanion hole and makes hydrogen bond contacts with Gln-19 and Cys-25.
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(as it appears on PubMed at http://www.pubmed.gov), where 8416808 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8416808}}
==About this Structure==
==About this Structure==
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[[Category: Crawford, C.]]
[[Category: Crawford, C.]]
[[Category: Schroder, E.]]
[[Category: Schroder, E.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:18:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:13:37 2008''

Revision as of 20:13, 27 July 2008

Image:1pop.png

Template:STRUCTURE 1pop

X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX

Template:ABSTRACT PUBMED 8416808

About this Structure

1POP is a Single protein structure. Full crystallographic information is available from OCA.

Reference

X-ray crystallographic structure of a papain-leupeptin complex., Schroder E, Phillips C, Garman E, Harlos K, Crawford C, FEBS Lett. 1993 Jan 2;315(1):38-42. PMID:8416808

Page seeded by OCA on Sun Jul 27 23:13:37 2008

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