1pp8

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[[Image:1pp8.gif|left|200px]]
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{{STRUCTURE_1pp8| PDB=1pp8 | SCENE= }}
{{STRUCTURE_1pp8| PDB=1pp8 | SCENE= }}
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'''crystal structure of the T. vaginalis IBP39 Initiator binding domain (IBD) bound to the alpha-SCS Inr element'''
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===crystal structure of the T. vaginalis IBP39 Initiator binding domain (IBD) bound to the alpha-SCS Inr element===
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==Overview==
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Transcription start site selection in eukaryotes is mediated through combinations of the TATA, initiator (Inr), and downstream promoter elements (DPE). In Trichomonas vaginalis, a parabasalian flagellate thought to represent an ancient eukaryote lineage, the Inr appears to be solely responsible for start site selection and is recognized by the initiator binding protein 39 kDa (IBP39). IBP39 contains an N-terminal Inr binding domain (IBD) connected via a flexible linker to a C-terminal domain (C domain). Here we present crystal structures of the apoIBD and IBD-Inr complexes and the C domain. The IBD structures reveal a winged-helix motif with prokaryotic and eukaryotic features and a scaffold similar to that of ETS-family proteins. The C domain structure and biochemical studies indicate that it interacts with the T. vaginalis RNAP II large subunit C-terminal domain. These data suggest that binding of IBP39 to the Inr directly recruits RNAP II and in this way initiates transcription.
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The line below this paragraph, {{ABSTRACT_PUBMED_14622596}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14622596 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14622596}}
==About this Structure==
==About this Structure==
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[[Category: T. vaginali]]
[[Category: T. vaginali]]
[[Category: Transcription]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:19:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:24:59 2008''

Revision as of 23:25, 28 July 2008

Image:1pp8.png

Template:STRUCTURE 1pp8

crystal structure of the T. vaginalis IBP39 Initiator binding domain (IBD) bound to the alpha-SCS Inr element

Template:ABSTRACT PUBMED 14622596

About this Structure

1PP8 is a Single protein structure of sequence from Trichomonas vaginalis. Full crystallographic information is available from OCA.

Reference

Structural basis of core promoter recognition in a primitive eukaryote., Schumacher MA, Lau AO, Johnson PJ, Cell. 2003 Nov 14;115(4):413-24. PMID:14622596

Page seeded by OCA on Tue Jul 29 02:24:59 2008

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