1ppg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ppg.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ppg.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ppg| PDB=1ppg | SCENE= }}
{{STRUCTURE_1ppg| PDB=1ppg | SCENE= }}
-
'''THE REFINED 2.3 ANGSTROMS CRYSTAL STRUCTURE OF HUMAN LEUKOCYTE ELASTASE IN A COMPLEX WITH A VALINE CHLOROMETHYL KETONE INHIBITOR'''
+
===THE REFINED 2.3 ANGSTROMS CRYSTAL STRUCTURE OF HUMAN LEUKOCYTE ELASTASE IN A COMPLEX WITH A VALINE CHLOROMETHYL KETONE INHIBITOR===
-
==Overview==
+
<!--
-
The stoichiometric complex formed between human leukocyte elastase and a synthetic MeO-Suc-Ala-Ala-Pro-Val chloromethyl ketone inhibitor was co-crystallized and its X-ray structure determined, using Patterson search methods. Its structure has been crystallographically refined to a final R value of 0.145 (8.0 and 2.3 A). The enzyme structure is very similar to that recently observed in a complex formed with the ovomucoid third domain from turkey [(1986) EMBO J. 5,2453-2458]. The rms deviation of all alpha-carbon atoms is 0.32 A. The peptidic inhibitor is bound in a similar overall conformation as the ovomucoid binding segment. Covalent bonds are formed between Val-P1 of the inhibitor and His-57 NE2 and Ser-195 OG of the enzyme. The carbonyl carbon is tetrahedrally deformed to a hemiketal. The valine side chain is arranged in the S1 pocket in the g-conformation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_3391280}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 3391280 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_3391280}}
==About this Structure==
==About this Structure==
Line 24: Line 28:
[[Category: Bode, W.]]
[[Category: Bode, W.]]
[[Category: Wei, A-Z.]]
[[Category: Wei, A-Z.]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:20:17 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:49:16 2008''

Revision as of 19:49, 27 July 2008

Image:1ppg.png

Template:STRUCTURE 1ppg

THE REFINED 2.3 ANGSTROMS CRYSTAL STRUCTURE OF HUMAN LEUKOCYTE ELASTASE IN A COMPLEX WITH A VALINE CHLOROMETHYL KETONE INHIBITOR

Template:ABSTRACT PUBMED 3391280

About this Structure

1PPG is a Single protein structure. Full crystallographic information is available from OCA.

Reference

The refined 2.3 A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor., Wei AZ, Mayr I, Bode W, FEBS Lett. 1988 Jul 18;234(2):367-73. PMID:3391280

Page seeded by OCA on Sun Jul 27 22:49:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ppg"
Personal tools