6swm
From Proteopedia
(Difference between revisions)
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<StructureSection load='6swm' size='340' side='right'caption='[[6swm]], [[Resolution|resolution]] 2.77Å' scene=''> | <StructureSection load='6swm' size='340' side='right'caption='[[6swm]], [[Resolution|resolution]] 2.77Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SWM FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LVW:(2~{R})-1-prop-2-enoxy-3-selanyl-propan-2-ol'>LVW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LVW:(2~{R})-1-prop-2-enoxy-3-selanyl-propan-2-ol'>LVW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6swm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6swm OCA], [https://pdbe.org/6swm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6swm RCSB], [https://www.ebi.ac.uk/pdbsum/6swm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6swm ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6swm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6swm OCA], [https://pdbe.org/6swm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6swm RCSB], [https://www.ebi.ac.uk/pdbsum/6swm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6swm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/CAH1_HUMAN CAH1_HUMAN] Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.<ref>PMID:10550681</ref> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Stable aryl selenols were obtained through a convenient procedure. Selenols represent a new chemotype acting as carbonic anhydrase inhibitors (CAIs), inhibiting four human isoforms, CAs I, II, VII and the tumor-associated CA IX. X-ray crystallographic, physical and computational studies provided insights into the binding mode of this conceptually new class of CAIs. | ||
| - | |||
| - | Selenols: a new class of carbonic anhydrase inhibitors.,Angeli A, Tanini D, Nocentini A, Capperucci A, Ferraroni M, Gratteri P, Supuran CT Chem Commun (Camb). 2018 Dec 18. doi: 10.1039/c8cc08562e. PMID:30560259<ref>PMID:30560259</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 6swm" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]] | *[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Angeli A]] | [[Category: Angeli A]] | ||
[[Category: Ferraroni M]] | [[Category: Ferraroni M]] | ||
Current revision
selenol bound carbonic anhydrase I
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