1pq1

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[[Image:1pq1.jpg|left|200px]]
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{{STRUCTURE_1pq1| PDB=1pq1 | SCENE= }}
{{STRUCTURE_1pq1| PDB=1pq1 | SCENE= }}
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'''Crystal structure of Bcl-xl/Bim'''
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===Crystal structure of Bcl-xl/Bim===
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==Overview==
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After antigen-driven expansion, the majority of T cells involved in an immune response die rapidly by apoptosis dependent on the Bcl-2 related proteins, Bim and Bax or Bak. The details of how these proteins are activated and interact are still unclear. The crystal structure of mouse Bcl-x(L) bound to a long helical fragment of Bim indicates that the structure of Bim is very different from proteins with a Bcl-2-like fold and may leave the BH3 region of Bim constitutively exposed. Based on the structural homology between Bcl-x(L) and Bax, we predicted that binding of Bim to Bax would require displacement of the Bax penultimate alpha helix. Consistent with this prediction, truncation of this short helix was required for Bim/Bax interaction and led to spontaneous activation of Bax. Our results suggest a way in which both Bim and Bax/Bak might be required for activated T cell apoptosis.
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The line below this paragraph, {{ABSTRACT_PUBMED_14499110}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14499110 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14499110}}
==About this Structure==
==About this Structure==
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[[Category: Zhu, Y.]]
[[Category: Zhu, Y.]]
[[Category: Bcl-xl/bim]]
[[Category: Bcl-xl/bim]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:21:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:21:55 2008''

Revision as of 00:21, 28 July 2008

Image:1pq1.png

Template:STRUCTURE 1pq1

Crystal structure of Bcl-xl/Bim

Template:ABSTRACT PUBMED 14499110

About this Structure

1PQ1 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function., Liu X, Dai S, Zhu Y, Marrack P, Kappler JW, Immunity. 2003 Sep;19(3):341-52. PMID:14499110

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