1pq3

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{{STRUCTURE_1pq3| PDB=1pq3 | SCENE= }}
{{STRUCTURE_1pq3| PDB=1pq3 | SCENE= }}
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'''Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal'''
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===Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal===
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==Overview==
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Arginase is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of l-arginine to form l-ornithine and urea. The X-ray crystal structure of a fully active, truncated form of human arginase II complexed with a boronic acid transition state analogue inhibitor has been determined at 2.7 A resolution. This structure is consistent with the hydrolysis of l-arginine through a metal-activated hydroxide mechanism. Given that human arginase II appears to play a role in regulating l-arginine bioavailability to NO synthase in human penile corpus cavernosum smooth muscle, the inhibition of human arginase II is a potential new strategy for the treatment of erectile dysfunction [Kim, N. N., Cox, J. D., Baggio, R. F., Emig, F. A., Mistry, S., Harper, S. L., Speicher, D. W., Morris, S. M., Ash, D. E., Traish, A. M., and Christianson, D. W. (2001) Biochemistry 40, 2678-2688]. Since NO synthase is found in human clitoral corpus cavernosum and vagina, we hypothesized that human arginase II is similarly present in these tissues and functions to regulate l-arginine bioavailability to NO synthase. Accordingly, hemodynamic studies conducted with a boronic acid arginase inhibitor in vivo are summarized, suggesting that the extrahepatic arginase plays a role in both male and female sexual arousal. Therefore, arginase II is a potential target for the treatment of male and female sexual arousal disorders.
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==About this Structure==
==About this Structure==
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[[Category: Traish, A M.]]
[[Category: Traish, A M.]]
[[Category: Biosynthetic protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:14:19 2008''

Revision as of 16:14, 27 July 2008

Image:1pq3.png

Template:STRUCTURE 1pq3

Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal

Template:ABSTRACT PUBMED 12859189

About this Structure

1PQ3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Human arginase II: crystal structure and physiological role in male and female sexual arousal., Cama E, Colleluori DM, Emig FA, Shin H, Kim SW, Kim NN, Traish AM, Ash DE, Christianson DW, Biochemistry. 2003 Jul 22;42(28):8445-51. PMID:12859189

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