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1prg

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{{STRUCTURE_1prg| PDB=1prg | SCENE= }}
{{STRUCTURE_1prg| PDB=1prg | SCENE= }}
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'''LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA'''
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===LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA===
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==Overview==
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The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a ligand-dependent transcription factor that is important in adipocyte differentiation and glucose homeostasis and which depends on interactions with co-activators, including steroid receptor co-activating factor-1 (SRC-1). Here we present the X-ray crystal structure of the human apo-PPAR-gamma ligand-binding domain (LBD), at 2.2 A resolution; this structure reveals a large binding pocket, which may explain the diversity of ligands for PPAR-gamma. We also describe the ternary complex containing the PPAR-gamma LBD, the antidiabetic ligand rosiglitazone (BRL49653), and 88 amino acids of human SRC-1 at 2.3 A resolution. Glutamate and lysine residues that are highly conserved in LBDs of nuclear receptors form a 'charge clamp' that contacts backbone atoms of the LXXLL helices of SRC-1. These results, together with the observation that two consecutive LXXLL motifs of SRC-1 make identical contacts with both subunits of a PPAR-gamma homodimer, suggest a general mechanism for the assembly of nuclear receptors with co-activators.
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(as it appears on PubMed at http://www.pubmed.gov), where 9744270 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9744270}}
==About this Structure==
==About this Structure==
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[[Category: Thiazolidinedione]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:24:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:24:38 2008''

Revision as of 09:24, 29 July 2008

Image:1prg.png

Template:STRUCTURE 1prg

LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA

Template:ABSTRACT PUBMED 9744270

About this Structure

1PRG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma., Nolte RT, Wisely GB, Westin S, Cobb JE, Lambert MH, Kurokawa R, Rosenfeld MG, Willson TM, Glass CK, Milburn MV, Nature. 1998 Sep 10;395(6698):137-43. PMID:9744270

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