1psz

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{{STRUCTURE_1psz| PDB=1psz | SCENE= }}
{{STRUCTURE_1psz| PDB=1psz | SCENE= }}
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'''PNEUMOCOCCAL SURFACE ANTIGEN PSAA'''
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===PNEUMOCOCCAL SURFACE ANTIGEN PSAA===
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==Overview==
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Background:. The surface protein PsaA of the pathogenic bacterium Streptococcus pneumoniae plays an essential role in its virulence. PsaA is a putative ATP-binding cassette-type (ABC-type) binding protein involved in the uptake of Mn2+ and possibly Zn2+ and is considered to be both a potential drug target and and a candidate vaccine component. Results:. The structure of PsaA has been determined to 2.0 A resolution using X-ray crystallography and is the first structure obtained for an ABC-type binding protein from a Gram-positive organism. The protein consists of two (beta/alpha)4 domains linked together by a single helix. A metal-binding site is formed in the domain interface by the sidechains of His67, His139, Glu205 and Asp280 and is occupied in the structure. Conclusions:. The structural topology of PsaA is fundamentally different from that of other ABC-type binding proteins determined thus far in that PsaA lacks the characteristic 'hinge peptides' involved in conformational change upon solute uptake and release. In our structure, the metal-binding site is probably occupied by Zn2+. The site seems to be well conserved amongst related receptors from both Gram-positive and Gram-negative bacteria.
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(as it appears on PubMed at http://www.pubmed.gov), where 9862808 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9862808}}
==About this Structure==
==About this Structure==
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[[Category: Pneumococcal surface antigen]]
[[Category: Pneumococcal surface antigen]]
[[Category: Psaa]]
[[Category: Psaa]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:43:17 2008''

Revision as of 04:43, 29 July 2008

Image:1psz.png

Template:STRUCTURE 1psz

PNEUMOCOCCAL SURFACE ANTIGEN PSAA

Template:ABSTRACT PUBMED 9862808

About this Structure

1PSZ is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.

Reference

The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein., Lawrence MC, Pilling PA, Epa VC, Berry AM, Ogunniyi AD, Paton JC, Structure. 1998 Dec 15;6(12):1553-61. PMID:9862808

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