1ptv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ptv.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ptv.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ptv| PDB=1ptv | SCENE= }}
{{STRUCTURE_1ptv| PDB=1ptv | SCENE= }}
-
'''CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE'''
+
===CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE===
-
==Overview==
+
<!--
-
The crystal structures of a cysteine-215--&gt;serine mutant of protein tyrosine phosphatase 1B complexed with high-affinity peptide substrates corresponding to an autophosphorylation site of the epidermal growth factor receptor were determined. Peptide binding to the protein phosphatase was accompanied by a conformational change of a surface loop that created a phosphotyrosine recognition pocket and induced a catalytically competent form of the enzyme. The phosphotyrosine side chain is buried within the period and anchors the peptide substrate to its binding site. Hydrogen bonds between peptide main-chain atoms and the protein contribute to binding affinity, and specific interactions of acidic residues of the peptide with basic residues on the surface of the enzyme confer sequence specificity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_7540771}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 7540771 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_7540771}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Peptide]]
[[Category: Peptide]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:28:37 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:38:56 2008''

Revision as of 16:39, 27 July 2008

Image:1ptv.png

Template:STRUCTURE 1ptv

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE

Template:ABSTRACT PUBMED 7540771

About this Structure

1PTV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B., Jia Z, Barford D, Flint AJ, Tonks NK, Science. 1995 Jun 23;268(5218):1754-8. PMID:7540771

Page seeded by OCA on Sun Jul 27 19:38:56 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ptv"
Personal tools