8iq4

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Current revision (09:44, 17 October 2024) (edit) (undo)
 
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<table><tr><td colspan='2'>[[8iq4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IQ4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[8iq4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IQ4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=87Q:Z-7-[(1R,2R,3R,5S)-2-[(E,3S)-3-methyl-3-oxidanyl-oct-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic+acid'>87Q</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=87Q:(~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E},3~{S})-3-methyl-3-oxidanyl-oct-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic+acid'>87Q</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iq4 OCA], [https://pdbe.org/8iq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iq4 RCSB], [https://www.ebi.ac.uk/pdbsum/8iq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iq4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iq4 OCA], [https://pdbe.org/8iq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iq4 RCSB], [https://www.ebi.ac.uk/pdbsum/8iq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iq4 ProSAT]</span></td></tr>
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== Function ==
 
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[https://www.uniprot.org/uniprot/PF2R_HUMAN PF2R_HUMAN] Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.<ref>PMID:18587449</ref>
 
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Current revision

Cryo-EM structure of Carboprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex

PDB ID 8iq4

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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