1rlb
From Proteopedia
(New page: 200px<br /> <applet load="1rlb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rlb, resolution 3.1Å" /> '''RETINOL BINDING PROT...) |
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| - | [[Image:1rlb.gif|left|200px]]<br /> | + | [[Image:1rlb.gif|left|200px]]<br /><applet load="1rlb" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1rlb" size=" | + | |
caption="1rlb, resolution 3.1Å" /> | caption="1rlb, resolution 3.1Å" /> | ||
'''RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN'''<br /> | '''RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The three-dimensional structure of the complex formed by two plasma | + | The three-dimensional structure of the complex formed by two plasma proteins, transthyretin and retinol-binding protein, was determined from x-ray diffraction data to a nominal resolution of 3.1 angstroms. One tetramer of transthyretin was bound to two molecules of retinol-binding protein. The two retinol-binding protein molecules established molecular interactions with the same transthyretin dimer, and each also made contacts with one of the other two monomers. Thus, the other two potential binding sites in a transthyretin tetramer were blocked. The amino acid residues of the retinol-binding protein that were involved in the contacts were close to the retinol-binding site. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1RLB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with REA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1RLB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=REA:'>REA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RLB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Coda, A.]] | [[Category: Coda, A.]] | ||
| - | [[Category: Monaco, H | + | [[Category: Monaco, H L.]] |
[[Category: Rizzi, M.]] | [[Category: Rizzi, M.]] | ||
[[Category: REA]] | [[Category: REA]] | ||
[[Category: complex (protein/protein)]] | [[Category: complex (protein/protein)]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:52:07 2008'' |
Revision as of 12:52, 21 February 2008
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RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN
Contents |
Overview
The three-dimensional structure of the complex formed by two plasma proteins, transthyretin and retinol-binding protein, was determined from x-ray diffraction data to a nominal resolution of 3.1 angstroms. One tetramer of transthyretin was bound to two molecules of retinol-binding protein. The two retinol-binding protein molecules established molecular interactions with the same transthyretin dimer, and each also made contacts with one of the other two monomers. Thus, the other two potential binding sites in a transthyretin tetramer were blocked. The amino acid residues of the retinol-binding protein that were involved in the contacts were close to the retinol-binding site.
Disease
Known diseases associated with this structure: Amyloid neuropathy, familial, several allelic types OMIM:[176300], Amyloidosis, senile systemic OMIM:[176300], Carpal tunnel syndrome, familial OMIM:[176300], Dystransthyretinemic hyperthyroxinemia OMIM:[176300], Retinol binding protein, deficiency of OMIM:[180250]
About this Structure
1RLB is a Protein complex structure of sequences from Gallus gallus and Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein., Monaco HL, Rizzi M, Coda A, Science. 1995 May 19;268(5213):1039-41. PMID:7754382
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