6sqc
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sqc OCA], [https://pdbe.org/6sqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sqc RCSB], [https://www.ebi.ac.uk/pdbsum/6sqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sqc ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sqc OCA], [https://pdbe.org/6sqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sqc RCSB], [https://www.ebi.ac.uk/pdbsum/6sqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sqc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[https://omim.org/entry/180849 180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Crystal structure of complex between nuclear coactivator binding domain of CBP and [1040-1086]ACTR containing alpha-methylated Leu1055 and Leu1076
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Categories: Escherichia coli K-12 | Homo sapiens | Large Structures | Bauer V | Cousido-Siah A | Dolenc j | Gogl G | Kieffer B | Kostmann C | Mitschler A | Osz J | Rochel N | Schmidtgall B | Torbeev V | Trave G
