1pue

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{{STRUCTURE_1pue| PDB=1pue | SCENE= }}
{{STRUCTURE_1pue| PDB=1pue | SCENE= }}
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'''PU.1 ETS DOMAIN-DNA COMPLEX'''
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===PU.1 ETS DOMAIN-DNA COMPLEX===
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==Overview==
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The Ets family of transcription factors, of which there are now about 35 members regulate gene expression during growth and development. They share a conserved domain of around 85 amino acids which binds as a monomer to the DNA sequence 5'-C/AGGAA/T-3'. We have determined the crystal structure of an ETS domain complexed with DNA, at 2.3-A resolution. The domain is similar to alpha + beta (winged) 'helix-turn-helix' proteins and interacts with a ten-base-pair region of duplex DNA which takes up a uniform curve of 8 degrees. The domain contacts the DNA by a novel loop-helix-loop architecture. Four of amino acids that directly interact with the DNA are highly conserved: two arginines from the recognition helix lying in the major groove, one lysine from the 'wing' that binds upstream of the core GGAA sequence, and another lysine, from the 'turn' of the 'helix-turn-helix' motif, which binds downstream and on the opposite strand.
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(as it appears on PubMed at http://www.pubmed.gov), where 8602247 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8602247}}
==About this Structure==
==About this Structure==
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[[Category: Oncogene]]
[[Category: Oncogene]]
[[Category: Transforming protein]]
[[Category: Transforming protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:29:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:47:00 2008''

Revision as of 19:47, 27 July 2008

Image:1pue.png

Template:STRUCTURE 1pue

PU.1 ETS DOMAIN-DNA COMPLEX

Template:ABSTRACT PUBMED 8602247

About this Structure

1PUE is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex., Kodandapani R, Pio F, Ni CZ, Piccialli G, Klemsz M, McKercher S, Maki RA, Ely KR, Nature. 1996 Apr 4;380(6573):456-60. PMID:8602247

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