7a6q

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Current revision (06:29, 1 October 2025) (edit) (undo)
 
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<StructureSection load='7a6q' size='340' side='right'caption='[[7a6q]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
<StructureSection load='7a6q' size='340' side='right'caption='[[7a6q]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7a6q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A6Q FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A6Q FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=R2K:(3-oxidanylidene-3-sodiooxy-propanoyl)oxysodium'>R2K</scene>, <scene name='pdbligand=R2Q:3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile'>R2Q</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=R2K:(3-oxidanylidene-3-sodiooxy-propanoyl)oxysodium'>R2K</scene>, <scene name='pdbligand=R2Q:3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile'>R2Q</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a6q OCA], [https://pdbe.org/7a6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a6q RCSB], [https://www.ebi.ac.uk/pdbsum/7a6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a6q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a6q OCA], [https://pdbe.org/7a6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a6q RCSB], [https://www.ebi.ac.uk/pdbsum/7a6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a6q ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[https://www.uniprot.org/uniprot/AL1A3_HUMAN AL1A3_HUMAN] Isolated anophthalmia - microphthalmia. The disease is caused by mutations affecting the gene represented in this entry.
 
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== Function ==
 
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[https://www.uniprot.org/uniprot/AL1A3_HUMAN AL1A3_HUMAN] Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).
 
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Garavaglia S]]
[[Category: Garavaglia S]]
[[Category: Gelardi ELM]]
[[Category: Gelardi ELM]]

Current revision

Crystal structure of human aldehyde dehydrogenase 1A3 in complex with selective NR6 inhibitor compound

PDB ID 7a6q

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