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1pvs

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{{STRUCTURE_1pvs| PDB=1pvs | SCENE= }}
{{STRUCTURE_1pvs| PDB=1pvs | SCENE= }}
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'''3-methyladenine Glcosylase II(AlkA) Hypoxanthine complex'''
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===3-methyladenine Glcosylase II(AlkA) Hypoxanthine complex===
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==Overview==
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Escherichia coli (E. coli) protein 3-methyladenine-DNA glycosylase II (AlkA) functions primarily by removing alkylation damage from duplex and single stranded DNA. A crystal structure of AlkA was refined to 2.0 A resolution. This structure in turn was used to refine an AlkA-hypoxanthine (substrate) complex structure to 2.4 A resolution. The complex structure shows hypoxanthine located in AlkA's active site stacked between residues W218 and Y239. The structural analysis of the AlkA and AlkA-hypoxanthine structures indicate that free hypoxanthine binding in the active site may inhibit glycosylase activity.
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{{ABSTRACT_PUBMED_12009927}}
==About this Structure==
==About this Structure==
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[[Category: Hypoxanthine]]
[[Category: Hypoxanthine]]
[[Category: Reaction-product complex]]
[[Category: Reaction-product complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:32:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:46:27 2008''

Revision as of 10:46, 27 July 2008

Image:1pvs.png

Template:STRUCTURE 1pvs

3-methyladenine Glcosylase II(AlkA) Hypoxanthine complex

Template:ABSTRACT PUBMED 12009927

About this Structure

1PVS is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

3-methyladenine-DNA glycosylase II: the crystal structure of an AlkA-hypoxanthine complex suggests the possibility of product inhibition., Teale M, Symersky J, DeLucas L, Bioconjug Chem. 2002 May-Jun;13(3):403-7. PMID:12009927

Page seeded by OCA on Sun Jul 27 13:46:27 2008

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